calcinosis
Pronunciation: kal-si-NO-sis
Abnormal calcium phosphate deposits in soft tissues, a serious complication of juvenile dermatomyositis.
Full Definition
Calcinosis refers to the pathological deposition of calcium phosphate salts in soft tissues, occurring in 30-70% of children with juvenile dermatomyositis. These deposits typically develop in muscle, subcutaneous tissue, and fascia, particularly around areas of previous inflammation or trauma. Calcinosis can cause significant functional impairment, pain, and cosmetic concerns, and may lead to skin breakdown and secondary infection. The deposits appear as white, chalky nodules on examination and are readily visible on radiographic imaging. Prevention through early aggressive treatment of the underlying inflammatory process is preferred, as established calcinosis is difficult to treat.
Usage
Usage note: Specify anatomical location and relationship to underlying inflammatory disease when documenting.
In Context
- "The patient developed extensive calcinosis despite aggressive immunosuppressive therapy for juvenile dermatomyositis." — Complication documentation
- "Plain radiographs demonstrated calcinosis in the patient's thigh muscles and surrounding fascia." — Radiology report