C3 hypocomplementemia
Pronunciation: C-three high-po-kom-ple-men-TEE-mee-ah
Abnormally low levels of complement component C3, often indicating complement consumption in pediatric autoimmune diseases.
Full Definition
C3 hypocomplementemia refers to decreased serum levels of complement component 3, a key protein in the complement cascade that plays crucial roles in immune defense and inflammation. In pediatric rheumatology, low C3 levels often indicate active complement consumption, particularly in systemic lupus erythematosus where immune complexes activate the classical complement pathway. C3 levels may also be reduced in other conditions including some forms of glomerulonephritis, cryoglobulinemia, or hereditary complement deficiencies. Monitoring C3 levels alongside C4 and CH50 provides important information about disease activity and treatment response in children with autoimmune conditions.
Usage
Usage note: Specify 'C3' rather than 'complement 3'; often measured alongside C4 and CH50.
In Context
- "Laboratory results revealed C3 hypocomplementemia with normal C4 levels, suggesting alternative pathway activation." — Laboratory interpretation
- "The patient's C3 hypocomplementemia normalized after achieving disease remission with immunosuppressive therapy." — Treatment response documentation