enthesitis-related arthritis
Pronunciation: en-the-SY-tis
Also written as: ERA — enthesitis-related arthritis
A JIA subtype characterized by inflammation at tendon insertion sites, often progressing to adult spondyloarthropathy.
Full Definition
Enthesitis-related arthritis (ERA) is a distinct subtype of juvenile idiopathic arthritis characterized by inflammation at entheses (sites where tendons, ligaments, or joint capsules attach to bone). This condition predominantly affects older boys and commonly involves the lower extremities, particularly the knees, ankles, and feet. Many patients carry the HLA-B27 genetic marker and may develop axial involvement including sacroiliitis. ERA represents the pediatric equivalent of adult spondyloarthropathies and often evolves into ankylosing spondylitis or related conditions in adulthood.
Usage
Usage note: Distinguish from other JIA subtypes by emphasizing entheseal involvement in documentation.
In Context
- "The adolescent male presented with enthesitis-related arthritis affecting his Achilles tendon insertions." — Clinical examination
- "HLA-B27 testing was positive in this patient with enthesitis-related arthritis and family history of ankylosing spondylitis." — Genetic testing report