NOMID
Also written as: NOMID — Neonatal-Onset Multisystem Inflammatory Disease
Neonatal-Onset Multisystem Inflammatory Disease, the most severe form of cryopyrin-associated periodic syndrome.
Full Definition
Neonatal-Onset Multisystem Inflammatory Disease (NOMID) is the most severe phenotype within the CAPS spectrum, typically presenting in the neonatal period. Patients exhibit persistent systemic inflammation with fever, urticarial rash, arthropathy with bony overgrowth, chronic aseptic meningitis, sensorineural hearing loss, and distinctive ophthalmologic findings including conjunctivitis and papilledema. The condition is also known as chronic infantile neurologic, cutaneous, and articular syndrome (CINCA). Early diagnosis and IL-1 inhibition therapy are crucial to prevent irreversible organ damage.
Usage
Usage note: May also be referred to as CINCA syndrome in European literature.
In Context
- "The infant's triad of persistent rash, arthropathy, and chronic meningitis was consistent with NOMID." — Pediatric rheumatology consultation
- "Early initiation of canakinumab prevented further neurologic deterioration in this NOMID patient." — Treatment protocol note