subcutaneous calcinosis
Abnormal calcium and phosphate deposits in subcutaneous tissues, a potential complication of juvenile inflammatory myopathy.
Full Definition
Subcutaneous calcinosis refers to the pathological deposition of calcium phosphate crystals in the subcutaneous tissue and sometimes in muscle fascia or tendons. In pediatric rheumatology, this complication occurs most commonly in children with juvenile dermatomyositis, particularly in those with delayed diagnosis, inadequate treatment, or certain genetic factors. The deposits can range from small, asymptomatic nodules to large, painful masses that may ulcerate through the skin and become infected. Calcinosis typically develops months to years after disease onset and can be progressive, causing significant functional impairment and cosmetic concerns. Treatment is challenging and may include calcium channel blockers, bisphosphonates, or surgical removal in severe cases.
Usage
Usage note: Distinguish from other forms of pathologic calcification; often a late complication.
In Context
- "Progressive subcutaneous calcinosis developed despite achieving clinical remission of the dermatomyositis." — Follow-up documentation
- "The radiograph revealed extensive subcutaneous calcinosis throughout the proximal muscle groups." — Imaging report interpretation