TRAPS
Also written as: TRAPS — TNF Receptor-Associated Periodic Syndrome
TNF Receptor-Associated Periodic Syndrome, an autoinflammatory disorder caused by mutations in the TNFRSF1A gene.
Full Definition
TNF Receptor-Associated Periodic Syndrome (TRAPS) is an autosomal dominant autoinflammatory disorder caused by mutations in the TNFRSF1A gene, which encodes the TNF receptor 1. Patients experience prolonged fever episodes lasting days to weeks, accompanied by migratory myalgia, arthralgia, abdominal pain, and characteristic skin rashes including erythematous patches and periorbital edema. Unlike other periodic fever syndromes, TRAPS episodes tend to be longer and less predictable. Complications may include AA amyloidosis. Treatment typically involves corticosteroids for acute episodes and IL-1 inhibitors or other biologics for prevention.
Usage
Usage note: Always spell out on first use; note prolonged episode duration compared to other periodic fevers.
In Context
- "The patient's prolonged fever episodes and migratory rash pattern were consistent with TRAPS rather than PFAPA syndrome." — Differential diagnosis note
- "Genetic testing confirmed a pathogenic TNFRSF1A mutation, establishing the diagnosis of TRAPS." — Genetic counseling report