reflux nephropathy
Kidney scarring and damage resulting from chronic vesicoureteral reflux and associated urinary tract infections.
Full Definition
Reflux nephropathy represents permanent kidney damage caused by the combination of vesicoureteral reflux and recurrent urinary tract infections. The condition involves scarring of renal parenchyma, particularly affecting the renal cortex and leading to reduced kidney function. Early detection and management of reflux can prevent progression to nephropathy, making it a critical concern in pediatric urology. The term encompasses both the acute inflammatory changes and chronic scarring patterns visible on imaging. Reflux nephropathy may progress to chronic kidney disease and hypertension in severe cases.
Usage
Usage note: Distinguish from acute infection; implies permanent structural damage.
In Context
- "DMSA scan revealed evidence of reflux nephropathy in the upper pole of the left kidney." — Nuclear medicine report
- "The patient developed reflux nephropathy despite early antibiotic prophylaxis." — Follow-up consultation note