tocolytic
Pronunciation: toe-ko-LIT-ik
Medication used to suppress uterine contractions and delay preterm labor.
Full Definition
Tocolytics are medications specifically designed to inhibit uterine contractions and prolong pregnancy in cases of preterm labor. Common tocolytic agents include beta-2 agonists (terbutaline), calcium channel blockers (nifedipine), magnesium sulfate, and prostaglandin inhibitors (indomethacin). These medications work through different mechanisms to relax uterine smooth muscle and are typically used to delay delivery long enough to administer antenatal corticosteroids for fetal lung maturity or facilitate maternal transfer to a higher-level care facility. Tocolytics are generally most effective when used between 24-34 weeks of gestation and may have maternal side effects requiring careful monitoring.
Usage
Usage note: Often confused with uterotonic (which stimulates contractions); these are opposite effects.
In Context
- "Tocolytic therapy with nifedipine successfully delayed delivery for 48 hours to complete the steroid course." — Labor and delivery note
- "Contraindications to tocolytic use include chorioamnionitis and severe preeclampsia." — Clinical protocol