BIA-ALCL
Also written as: BIA-ALCL — Breast Implant-Associated Anaplastic Large Cell Lymphoma
Rare lymphoma associated with textured breast implants requiring specialized diagnosis and treatment.
Full Definition
BIA-ALCL (Breast Implant-Associated Anaplastic Large Cell Lymphoma) is a rare form of T-cell lymphoma that can develop in the scar tissue capsule surrounding breast implants, particularly those with textured surfaces. This condition typically presents as a late seroma (fluid collection) developing years after implant placement, breast asymmetry, or palpable masses around the implant. Diagnosis requires cytological or histological examination of fluid or tissue specimens, with specific immunohistochemical markers (CD30 positive, ALK negative). Treatment usually involves complete surgical removal of the implant and surrounding capsule (en bloc capsulectomy). While the overall incidence is very low, the association with textured implants has led to increased awareness and changes in implant selection practices globally.
Usage
Usage note: Serious condition requiring immediate evaluation; document any suspicious findings promptly.
In Context
- "The patient's late-onset unilateral seroma raised suspicion for BIA-ALCL and prompted immediate cytological analysis." — Urgent consultation note
- "BIA-ALCL diagnosis was confirmed by CD30 positive immunohistochemistry on the capsule specimen." — Pathology report