BRCA1/2 wild-type
The normal, unmutated form of BRCA1 or BRCA2 genes, indicating intact homologous recombination repair capacity.
Full Definition
BRCA1/2 wild-type refers to the normal, functional versions of the BRCA1 and BRCA2 genes without pathogenic mutations. Patients with wild-type BRCA genes retain intact homologous recombination DNA repair mechanisms, which affects treatment selection in cancers such as ovarian, breast, pancreatic, and prostate cancers. Unlike patients with BRCA mutations, those with wild-type status are less likely to respond to PARP inhibitors and may not benefit from platinum-based chemotherapy to the same extent.
Usage
Usage note: Use 'wild-type' with hyphen. BRCA1/2 indicates either or both genes. Distinguish from BRCA-positive, which refers to mutation presence.
In Context
- "The patient's BRCA1/2 wild-type status indicated minimal benefit from olaparib therapy." — Genetic testing report
- "BRCA1/2 wild-type ovarian cancers require different therapeutic approaches than hereditary cases." — Treatment guideline