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Professional Technical In the Industry Vocabulary Test

CAR-T cell therapy

Pronunciation: car-T cell therapy

Also written as: CAR-T — Chimeric Antigen Receptor T-cell

Chimeric antigen receptor T-cell therapy using genetically modified immune cells to target cancer.

Full Definition

Chimeric antigen receptor T-cell therapy represents a groundbreaking immunotherapy approach where a patient's T-cells are genetically engineered to express artificial receptors that recognize specific cancer antigens. The modified cells are expanded in the laboratory and reinfused to mount a targeted immune response against malignant cells. This complex treatment requires specialized manufacturing capabilities and intensive monitoring for potentially life-threatening side effects including cytokine release syndrome.

Usage

Usage note: Hyphenate CAR-T. Maintain consistent capitalization throughout documents.

In Context

  • "The patient was evaluated for CAR-T cell therapy following failure of three prior treatment regimens." — Oncology consultation
  • "Manufacturing delays postponed the scheduled CAR-T cell therapy infusion by two weeks." — Treatment scheduling update

Also known as

chimeric antigen receptor T-cell therapy CAR T-cell therapy

Contrasted with

conventional chemotherapy radiation therapy

Don't confuse with

TCR therapy TIL therapy
BRCA1/2 wild-type ← Back to glossary chromosomal instability score

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