Intermediate Technical IVT

NGS

Also written as: NGS — Next-Generation Sequencing

Next-generation sequencing technology used for comprehensive genomic analysis in cancer diagnosis.

Full Definition

Next-generation sequencing represents a revolutionary approach to DNA and RNA analysis that enables rapid, cost-effective sequencing of entire genomes or targeted gene panels. In precision oncology, NGS is fundamental for identifying mutations, copy number variations, and gene fusions that inform treatment decisions. The technology has largely replaced single-gene testing approaches in modern cancer care.

Usage

Usage note: Always capitalize. Spell out on first use in patient-facing documents.

In Context

"The NGS panel revealed multiple clinically significant variants requiring further analysis." — Laboratory report
"Insurance pre-authorization was required before proceeding with the comprehensive NGS assay." — Prior authorization form

Also known as

next-generation sequencing high-throughput sequencing

Contrasted with

Sanger sequencing single-gene testing

Don't confuse with

PCR FISH

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