tumor molecular profile
A comprehensive analysis of genetic, epigenetic, and protein alterations present in a cancer specimen to guide treatment decisions.
Full Definition
Tumor molecular profiling encompasses systematic analysis of cancer-specific molecular alterations including mutations, copy number changes, gene fusions, protein expression, and sometimes epigenetic modifications. This comprehensive characterization enables precision medicine approaches by identifying actionable targets, predicting treatment responses, and stratifying patient risk. Profiling methods range from targeted gene panels to whole genome sequencing, often combined with immunohistochemistry and other assays. The resulting molecular profile informs treatment selection, clinical trial enrollment, and prognostic assessment.
Usage
Usage note: May be abbreviated as TMP in some contexts; ensure clarity about scope of analysis included.
In Context
- "The tumor molecular profile identified BRAF V600E mutation and MSI-high status." — Precision oncology report
- "Comprehensive tumor molecular profiling is now standard of care for advanced cancers." — Clinical practice guideline