Professional
Technical
IVT
tumor mutational burden
The total number of mutations per megabase of DNA in a tumor sample, used to predict immunotherapy response.
Full Definition
Tumor mutational burden quantifies the number of somatic mutations present in a tumor specimen, typically expressed as mutations per megabase of sequenced DNA. High TMB is associated with increased neoantigen production and enhanced immune recognition, making it a predictive biomarker for response to immune checkpoint inhibitors. The measurement requires standardized methodologies and careful interpretation in clinical contexts.
Usage
Usage note: Often abbreviated as TMB in subsequent references. Hyphenate when used as compound modifier.
In Context
- "The patient's tumor mutational burden of 15 mutations/Mb supported consideration of immunotherapy." — Oncology consultation note
- "Tumor mutational burden assessment was inconclusive due to insufficient tissue quality." — Pathology report addendum
Also known as
TMB
mutational load
Contrasted with
microsatellite stable
low mutation rate
Don't confuse with
tumor mutation frequency
allelic frequency