FISH
Also written as: FISH — Fluorescence In Situ Hybridization
Fluorescence in situ hybridization; rapid genetic test using fluorescent probes.
Full Definition
Fluorescence in situ hybridization is a molecular cytogenetic technique that uses fluorescent DNA probes to detect specific chromosomal abnormalities or gene sequences. In prenatal diagnosis, FISH is commonly used for rapid detection of common trisomies (13, 18, 21) and sex chromosome aneuploidies, providing results within 24-48 hours compared to traditional karyotyping. While faster than conventional methods, FISH only tests for specific targeted conditions and may miss other chromosomal abnormalities.
Usage
Usage note: Specify which probes were used (e.g., FISH for chromosomes 13, 18, 21, X, Y).
In Context
- "FISH analysis confirmed trisomy 21 pending full karyotype results." — preliminary genetic report
- "Rapid FISH testing was ordered for immediate clinical decision-making." — laboratory requisition