Advanced
Technical
IVT
microarray
Pronunciation: MY-kro-uh-ray
High-resolution genetic test detecting small chromosomal deletions and duplications.
Full Definition
A sophisticated genetic testing technology that can detect submicroscopic chromosomal imbalances including microdeletions and microduplications that are too small to be seen with traditional karyotyping. Chromosomal microarray analysis (CMA) has higher resolution than conventional cytogenetics and can identify clinically significant genetic variants that cause intellectual disability, autism, and birth defects. In prenatal diagnosis, microarray is increasingly offered as a first-line test when invasive testing is performed.
Usage
Usage note: Specify type: SNP array or array CGH when relevant to interpretation.
In Context
- "Microarray analysis revealed a pathogenic deletion not visible on karyotype." — genetic laboratory report
- "The genetic counselor discussed microarray versus standard karyotyping options." — consultation notes
Also known as
chromosomal microarray
CMA
array CGH
Don't confuse with
karyotype
whole exome sequencing