coronary flow reserve
The ratio of maximal coronary blood flow during pharmacologic vasodilation to resting coronary blood flow.
Full Definition
Coronary flow reserve (CFR) measures the capacity of coronary circulation to increase blood flow in response to maximal pharmacologic vasodilation, typically achieved with adenosine, dipyridamole, or regadenoson. Normal CFR values are generally ≥2.0, indicating that coronary flow can at least double from baseline. Reduced CFR (<2.0) may indicate epicardial coronary stenosis, microvascular dysfunction, or both. CFR can be measured using various techniques including positron emission tomography (PET), cardiac MRI, or transthoracic echocardiography. This parameter provides important prognostic information and helps identify patients with coronary microvascular disease who may not have obstructive epicardial disease.
Usage
Usage note: CFR abbreviation acceptable after first use; distinguish clearly from fractional flow reserve (FFR).
In Context
- "PET imaging revealed a coronary flow reserve of 1.6, suggesting significant microvascular impairment." — Nuclear cardiology report
- "Normal coronary flow reserve findings helped exclude significant coronary microvascular dysfunction." — Diagnostic test interpretation