lipoprotein(a)
Pronunciation: LIE-poh-pro-teen-A
Also written as: Lp(a) — lipoprotein(a)
A genetic variant of LDL cholesterol associated with increased cardiovascular risk.
Full Definition
Lipoprotein(a) is a cholesterol-rich lipoprotein particle consisting of an LDL-like particle with an additional apolipoprotein(a) component. Elevated Lp(a) levels are largely genetically determined and represent an independent risk factor for atherosclerotic cardiovascular disease. Unlike other lipid parameters, Lp(a) levels respond poorly to lifestyle interventions and most conventional lipid-lowering therapies, making it an important consideration in risk assessment and treatment planning.
Usage
Usage note: Include parentheses around 'a'. Often abbreviated as Lp(a) in clinical documentation.
In Context
- "Elevated lipoprotein(a) levels above 50 mg/dL may warrant more aggressive LDL lowering targets." — Laboratory interpretation
- "The patient's family history and Lp(a) of 75 mg/dL supported early statin initiation." — Clinical decision note