MACE
Also written as: MACE — Major Adverse Cardiovascular Events
Composite endpoint used in cardiovascular trials, typically including cardiovascular death, myocardial infarction, and stroke.
Full Definition
Major Adverse Cardiovascular Events (MACE) is a standardized composite endpoint used in preventive cardiology research and clinical trials to measure cardiovascular outcomes. The traditional three-point MACE includes cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke. Extended definitions may include additional endpoints such as urgent revascularization or hospitalization for heart failure. MACE serves as a key metric for evaluating the efficacy of preventive interventions.
Usage
Usage note: MACE is often modified with numbers (3-point MACE, 4-point MACE) to specify included endpoints.
In Context
- "The trial demonstrated a 20% reduction in MACE with the new preventive therapy." — clinical research report
- "Patients should be counseled about their individual MACE risk based on current guidelines." — patient consultation note