suicidality
A broad term encompassing suicidal ideation, behaviors, and attempts, used as a safety endpoint in psychiatric trials.
Full Definition
Suicidality refers to the full spectrum of suicide-related thoughts and behaviors, including passive death wishes, active suicidal ideation, suicidal plans, preparatory behaviors, interrupted attempts, aborted attempts, and actual suicide attempts. In psychiatric research, suicidality assessment is mandatory for regulatory approval, typically measured using standardized instruments like the Columbia Suicide Severity Rating Scale (C-SSRS). The FDA requires careful monitoring and reporting of suicidality events, particularly in studies involving antidepressants in pediatric and young adult populations.
Usage
Usage note: Use 'suicidality' for the broad concept; 'suicidal ideation' for thoughts only.
In Context
- "All incidents of suicidality were adjudicated by an independent safety committee." — Safety monitoring plan
- "The study protocol included weekly suicidality assessments using the C-SSRS." — Safety procedures