discontinuation syndrome
Constellation of symptoms that occur when certain psychotropic medications are stopped abruptly or tapered too quickly.
Full Definition
Discontinuation syndrome refers to the physical and psychological symptoms that can occur when certain medications, particularly antidepressants and benzodiazepines, are stopped suddenly or reduced too rapidly. Unlike addiction withdrawal, discontinuation syndrome occurs even in patients taking therapeutic doses as prescribed. Symptoms may include flu-like symptoms, dizziness, electric shock sensations ('brain zaps'), mood changes, and anxiety. The syndrome is more common with medications that have shorter half-lives, such as paroxetine and venlafaxine. Prevention involves gradual tapering under medical supervision, and symptoms typically resolve within days to weeks.
Usage
Usage note: Preferred term over 'withdrawal' to avoid stigma associated with addiction.
In Context
- "The patient experienced discontinuation syndrome after stopping paroxetine abruptly." — medication review
- "A slow taper schedule was implemented to prevent discontinuation syndrome." — treatment plan