antipsychotic-induced parkinsonism
Motor disorder characterized by tremor, rigidity, and bradykinesia caused by dopamine receptor blockade from antipsychotic medications.
Full Definition
Antipsychotic-induced parkinsonism is a drug-induced movement disorder that mimics Parkinson's disease, resulting from dopamine receptor blockade in the nigrostriatal pathway. Symptoms include tremor, muscle rigidity, bradykinesia (slow movement), and shuffling gait. This condition typically develops within days to weeks of starting antipsychotic treatment or increasing doses. Unlike idiopathic Parkinson's disease, this condition is usually reversible when the causative medication is discontinued or the dose is reduced. It is more common with first-generation antipsychotics but can occur with second-generation agents as well.
Usage
Usage note: Always hyphenate when used as a compound adjective; distinguish from other movement disorders in clinical documentation.
In Context
- "The patient developed antipsychotic-induced parkinsonism after three weeks on haloperidol therapy." — Clinical assessment report
- "Differential diagnosis must distinguish between antipsychotic-induced parkinsonism and underlying movement disorders." — Treatment guideline