atypical antipsychotic
Second-generation antipsychotic medications with reduced risk of movement disorders compared to older agents.
Full Definition
A class of antipsychotic medications developed since the 1990s that demonstrate reduced propensity to cause extrapyramidal side effects compared to first-generation (typical) antipsychotics. Atypical antipsychotics, including risperidone, olanzapine, quetiapine, and aripiprazole, work through different receptor mechanisms and generally have more favorable side effect profiles regarding movement disorders. However, they carry increased risks of metabolic side effects like weight gain and diabetes. The term 'atypical' refers to their pharmacological profile rather than their therapeutic efficacy.
Usage
Usage note: Often abbreviated as SGA (second-generation antipsychotic) in clinical notes. Ensure parallel structure when comparing with 'typical' antipsychotics.
In Context
- "Atypical antipsychotics have largely replaced older agents due to their improved tolerability profile." — Clinical review
- "The patient experienced significant weight gain on the atypical antipsychotic despite good symptom control." — Case report