cross-tolerance
The phenomenon where tolerance to one substance reduces sensitivity to pharmacologically similar substances.
Full Definition
Cross-tolerance occurs when chronic exposure to one medication leads to reduced sensitivity not only to that drug but also to other medications with similar mechanisms of action. In psychopharmacology, this is particularly relevant with benzodiazepines, where tolerance to one benzodiazepine typically extends to others in the same class. Cross-tolerance also occurs between alcohol and benzodiazepines due to their similar effects on GABA receptors. Understanding cross-tolerance is important for medication switching, dose adjustments, and managing substance use disorders in patients receiving psychiatric treatment. It can complicate treatment decisions and affect medication effectiveness.
Usage
Usage note: Always hyphenate; refers to reduced sensitivity across drug classes, not individual drug tolerance.
In Context
- "Cross-tolerance between benzodiazepines may require higher doses when switching medications." — Medication transition plan
- "The patient's alcohol use history suggests potential cross-tolerance with prescribed anxiolytics." — Substance use assessment