discontinuation syndrome
A cluster of symptoms that occur when psychiatric medications are stopped abruptly or reduced too quickly.
Full Definition
Discontinuation syndrome refers to a constellation of physical and psychological symptoms that can emerge when psychotropic medications are abruptly stopped or tapered too rapidly. These symptoms are particularly common with medications that have short half-lives, such as paroxetine and venlafaxine. Common symptoms include flu-like symptoms, dizziness, electric shock sensations, anxiety, and mood changes. Discontinuation syndrome is not the same as addiction or withdrawal in the traditional sense, but rather represents the brain's adjustment to the absence of the medication. Gradual tapering schedules help minimize these effects.
Usage
Usage note: Preferred term over 'withdrawal syndrome' to avoid stigma and clarify it's not addiction-related.
In Context
- "The patient experienced discontinuation syndrome after abruptly stopping the SSRI." — Emergency department note
- "To prevent discontinuation syndrome, the antidepressant should be tapered gradually over several weeks." — Discharge instructions