pharmacokinetic interaction
Drug interaction affecting the absorption, distribution, metabolism, or elimination of medications.
Full Definition
A pharmacokinetic interaction occurs when one drug alters the absorption, distribution, metabolism, or elimination (ADME) processes of another drug, thereby changing its plasma concentration and potentially its therapeutic effect. These interactions differ from pharmacodynamic interactions, which involve changes at the receptor or target site level. Common pharmacokinetic interactions in psychopharmacology include CYP enzyme inhibition or induction affecting drug metabolism, competition for protein binding sites, and altered renal clearance. Understanding these interactions is crucial for predicting the need for dose adjustments when adding or discontinuing medications in polypharmacy regimens.
Usage
Usage note: Distinguish from pharmacodynamic interactions; specify ADME process involved when relevant.
In Context
- "The pharmacokinetic interaction between fluoxetine and clozapine requires careful monitoring of clozapine plasma levels." — Drug interaction assessment
- "Dose reduction is necessary when initiating the CYP inhibitor due to the anticipated pharmacokinetic interaction." — Medication adjustment protocol