SSRI
Pronunciation: ESS-ESS-ARE-EYE
Also written as: SSRI — selective serotonin reuptake inhibitor
Selective serotonin reuptake inhibitor, a class of antidepressant medications that increase serotonin availability in the brain.
Full Definition
SSRIs are the most commonly prescribed class of antidepressants, working by blocking the reabsorption of serotonin in brain synapses. This mechanism increases serotonin levels, which can improve mood and reduce anxiety. Common SSRIs include fluoxetine, sertraline, and escitalopram. In clinical documentation, SSRIs are often preferred as first-line treatment due to their generally favorable side effect profile compared to older antidepressant classes.
Usage
Usage note: Always capitalize all letters; do not use periods between letters.
In Context
- "The patient was started on an SSRI for treatment of major depressive disorder." — Discharge summary
- "SSRI discontinuation syndrome may occur if medication is stopped abruptly." — Patient education material