tricyclic antidepressant
A class of antidepressant medications characterized by their three-ring chemical structure, known for anticholinergic side effects and cardiotoxicity.
Full Definition
Tricyclic antidepressants (TCAs) are an older class of antidepressant medications that derive their name from their distinctive three-ring chemical structure. These medications work primarily by blocking the reuptake of norepinephrine and serotonin. While effective for depression and certain anxiety disorders, TCAs are associated with significant side effects including anticholinergic effects (dry mouth, constipation, blurred vision), sedation, and potentially fatal cardiotoxicity in overdose. They require careful monitoring, particularly in elderly patients and those with cardiac conditions.
Usage
Usage note: Often abbreviated as TCA in clinical documentation.
In Context
- "The patient's tricyclic antidepressant was tapered slowly to avoid withdrawal symptoms." — medication review notes
- "Due to cardiac contraindications, the tricyclic was discontinued in favor of an SSRI." — clinical assessment