granulosa cell tumor
Pronunciation: gran-you-LOW-sa
A rare ovarian tumor arising from granulosa cells that often produces estrogen and presents with hormonal symptoms.
Full Definition
Granulosa cell tumors are uncommon ovarian neoplasms that arise from the granulosa cells of the ovarian follicle. These tumors are typically estrogen-producing, leading to symptoms of hyperestrogenism such as irregular bleeding, endometrial hyperplasia, or precocious puberty in younger patients. In reproductive endocrinology, these tumors can significantly impact fertility and require careful hormonal evaluation. They have a characteristic pattern of late recurrence and generally have a better prognosis than other ovarian malignancies.
Usage
Usage note: Often abbreviated as 'GCT' in clinical documentation. Important to distinguish from granulosa cells in normal follicular development.
In Context
- "The pathology report confirmed a granulosa cell tumor with positive inhibin staining." — Surgical pathology report
- "Her irregular bleeding was attributed to the estrogen-producing granulosa cell tumor." — Clinical assessment