hyperandrogenism
Pronunciation: hahy-per-AN-druh-juh-nizm
Excessive male hormone production in women causing reproductive and metabolic dysfunction. A key feature of polycystic ovary syndrome.
Full Definition
Hyperandrogenism refers to the excessive production or activity of androgens (male hormones) in women, resulting in various clinical manifestations including hirsutism, acne, male-pattern baldness, and reproductive dysfunction. The condition can be caused by ovarian or adrenal disorders, with polycystic ovary syndrome being the most common etiology. Laboratory diagnosis involves measuring total and free testosterone, androstenedione, and DHEA-S levels. Clinical assessment includes evaluation of hirsutism using standardized scoring systems and assessment of other virilizing signs. Hyperandrogenism often leads to anovulation, menstrual irregularities, and infertility, requiring comprehensive reproductive endocrine evaluation. Treatment may include insulin sensitizers, anti-androgen medications, or ovulation induction agents depending on the underlying cause and patient goals.
Usage
Usage note: Distinguish between clinical hyperandrogenism (physical signs) and biochemical hyperandrogenism (laboratory findings).
In Context
- "Laboratory evaluation confirmed biochemical hyperandrogenism with elevated free testosterone levels." — Endocrine assessment report
- "Clinical hyperandrogenism was evident from the patient's hirsutism and irregular menstrual cycles." — Physical examination findings