hypergonadotropic hypogonadism
Condition where high levels of gonadotropins fail to stimulate adequate sex hormone production due to gonadal dysfunction.
Full Definition
Hypergonadotropic hypogonadism is a reproductive disorder characterized by elevated levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) with correspondingly low sex hormone production. This condition typically indicates primary gonadal failure, where the ovaries or testes are unable to respond appropriately to gonadotropic stimulation. In reproductive endocrinology, this diagnosis significantly impacts fertility treatment planning and prognosis. The condition may be congenital (such as Turner syndrome) or acquired through chemotherapy, radiation, or surgical removal of gonads.
Usage
Usage note: Distinguish from hypogonadotropic hypogonadism which involves low gonadotropins
In Context
- "The patient's elevated FSH levels indicated hypergonadotropic hypogonadism rather than hypothalamic dysfunction." — Clinical assessment report
- "Treatment options for hypergonadotropic hypogonadism are limited due to the primary gonadal failure." — Treatment planning document