zona drilling
Laboratory technique creating an opening in the zona pellucida to assist embryo hatching and implantation.
Full Definition
Zona drilling, also known as assisted hatching, is an embryological technique where a small opening is created in the zona pellucida of an embryo before transfer. This procedure is performed using various methods including acid solution, laser, or mechanical manipulation. The technique is typically recommended for patients with repeated implantation failure, advanced maternal age, elevated FSH levels, or when embryos have thick zona pellucida. The goal is to facilitate embryo hatching and improve implantation rates, though the procedure carries some risks including potential damage to the embryo or increased risk of monozygotic twinning.
Usage
Usage note: Often used interchangeably with 'assisted hatching'; specify method when relevant.
In Context
- "Zona drilling was performed on day 3 embryos prior to transfer." — Laboratory protocol
- "The embryologist recommended zona drilling due to the patient's advanced age." — Treatment plan