vitrification
Pronunciation: vit-rih-fih-KAY-shun
An ultra-rapid freezing technique for preserving embryos and oocytes. The preferred cryopreservation method in modern reproductive medicine.
Full Definition
Vitrification is an ultra-rapid cryopreservation technique that prevents ice crystal formation by instantaneously solidifying biological material into a glass-like state. In reproductive medicine, vitrification has largely replaced slow-freezing methods for preserving oocytes, embryos, and reproductive tissues due to superior survival rates and post-thaw developmental potential. The process involves exposure to high concentrations of cryoprotectants followed by extremely rapid cooling in liquid nitrogen. Vitrification requires precise timing and technique to minimize osmotic stress and cellular damage. This technology has revolutionized fertility preservation, enabling successful egg freezing for medical and elective reasons, and allowing flexible timing of embryo transfers in assisted reproductive technology cycles.
Usage
Usage note: Preferred over 'flash freezing' in medical contexts; ensure distinction from general cryopreservation techniques.
In Context
- "All surplus embryos were preserved using vitrification techniques with excellent post-thaw survival rates." — Embryology laboratory documentation
- "Oocyte vitrification allows women to preserve fertility prior to cancer treatment." — Fertility preservation consultation