mitochondrial replacement therapy
Reproductive technique to prevent transmission of mitochondrial diseases by replacing defective mitochondria.
Full Definition
Mitochondrial replacement therapy (MRT) encompasses several techniques designed to prevent the transmission of severe mitochondrial diseases from mother to child by replacing defective maternal mitochondria with healthy donor mitochondria. The primary methods include maternal spindle transfer and pronuclear transfer, both involving the transfer of nuclear DNA while leaving behind defective mitochondria. This controversial technique raises complex ethical, legal, and social issues while offering hope for families affected by devastating mitochondrial disorders.
Usage
Usage note: Highly specialized technique with significant regulatory and ethical considerations.
In Context
- "Mitochondrial replacement therapy was considered for this couple with a family history of Leigh syndrome." — Genetic counseling consultation
- "Regulatory approval for mitochondrial replacement therapy varies significantly between jurisdictions." — Policy review document