pseudomosaicism
Pronunciation: SOO-do-mo-ZAY-ih-sizm
Apparent mosaicism in cell culture that does not reflect the true genetic status of the individual.
Full Definition
Pseudomosaicism refers to the artifactual appearance of multiple cell lines with different chromosomal constitutions in cultured cells that does not accurately represent the true genetic composition of the individual being tested. This laboratory artifact commonly occurs in prenatal diagnosis when cell culture conditions cause chromosome loss or gain during mitotic divisions. Pseudomosaicism must be distinguished from true mosaicism through additional testing, as it can lead to incorrect genetic diagnoses and inappropriate clinical management decisions.
Usage
Usage note: Always distinguish from true mosaicism in reports and counseling discussions.
In Context
- "The cytogeneticist suspected pseudomosaicism when only a single abnormal cell was found among 20 analyzed metaphases." — Prenatal cytogenetic report
- "Follow-up amniocentesis was recommended to rule out pseudomosaicism in the CVS sample." — Genetic counseling note