wide local excision
Also written as: WLE — wide local excision
Surgical removal of tumor with a predetermined margin of normal tissue around the lesion.
Full Definition
Wide local excision (WLE) is a surgical technique involving the removal of a tumor along with a surrounding margin of apparently normal tissue. The width of the margin varies depending on the tumor type, location, and established clinical guidelines—typically ranging from 1-3 centimeters for most solid tumors. This approach aims to ensure complete tumor removal while preserving as much normal tissue and function as possible. WLE is commonly performed for breast cancer, melanoma, soft tissue sarcomas, and other solid tumors where organ preservation is feasible. The adequacy of excision is confirmed through careful histopathological examination of the surgical margins.
Usage
Usage note: Hyphenate when used as compound modifier. Abbreviation WLE does not use periods.
In Context
- "Wide local excision achieved clear margins with excellent cosmetic outcome." — Surgical report
- "The melanoma was treated with wide local excision using a 2-cm margin as per guidelines." — Treatment summary