androgen deprivation therapy
Also written as: ADT — androgen deprivation therapy
Hormonal treatment that reduces or blocks testosterone production to slow prostate cancer growth.
Full Definition
Androgen deprivation therapy (ADT) is a cornerstone treatment for advanced prostate cancer that works by reducing or eliminating testosterone and other male hormones that fuel cancer cell growth. The therapy can be achieved through surgical castration (orchiectomy) or medical castration using LHRH agonists or antagonists. ADT is often combined with other treatments and may be used in neoadjuvant, concurrent, or adjuvant settings. Side effects include hot flashes, osteoporosis, cardiovascular risks, and sexual dysfunction.
Usage
Usage note: Always spell out on first use, then use ADT abbreviation. Note hyphenation in full term.
In Context
- "The patient began androgen deprivation therapy with leuprolide injections every three months." — Treatment protocol
- "Long-term androgen deprivation therapy requires monitoring for bone density loss and cardiovascular complications." — Clinical guidance