lymphovascular space invasion
Presence of tumor cells within lymphatic or vascular channels, indicating aggressive tumor behavior and higher risk of metastasis.
Full Definition
Lymphovascular space invasion (LVSI) refers to the histologic finding of tumor cells within endothelium-lined lymphatic or vascular spaces adjacent to the primary tumor. This pathologic feature is associated with increased risk of local recurrence and distant metastasis across various urologic malignancies. LVSI is routinely reported in surgical pathology specimens and influences staging, prognosis, and treatment decisions. The presence of LVSI may prompt consideration of adjuvant therapy or more intensive surveillance protocols.
Usage
Usage note: Often abbreviated as LVSI in clinical documentation. Distinguish from perineural invasion, which involves nerve sheaths rather than vessels.
In Context
- "The pathology report documented extensive lymphovascular space invasion in the radical nephrectomy specimen." — Surgical pathology report
- "Given the presence of lymphovascular space invasion, the multidisciplinary team recommended adjuvant chemotherapy." — Treatment planning note