PSA doubling time
Also written as: PSADT — PSA doubling time
Time required for PSA levels to double, used to assess aggressiveness of recurrent prostate cancer.
Full Definition
PSA doubling time (PSADT) represents the calculated time required for prostate-specific antigen levels to double based on serial measurements, serving as a marker of tumor growth kinetics and aggressiveness. This parameter is particularly valuable in the setting of biochemical recurrence following radical treatment, where it helps distinguish indolent from aggressive disease. A shorter PSADT (typically less than 9-12 months) suggests more aggressive disease and may prompt earlier intervention, while longer doubling times may allow for continued observation. PSADT calculations require at least three PSA measurements over time and are influenced by measurement frequency and laboratory variability.
Usage
Usage note: Requires multiple PSA measurements for accurate calculation. Shorter doubling times generally indicate more aggressive disease.
In Context
- "The PSA doubling time of 6 months indicated aggressive disease requiring immediate salvage therapy." — Biochemical recurrence evaluation
- "With a PSA doubling time exceeding 24 months, continued active surveillance was deemed appropriate." — Follow-up consultation note