Gleason score
Pronunciation: GLEE-son
A grading system for prostate cancer based on histological appearance and architectural patterns.
Full Definition
The Gleason score is the standard histopathological grading system for prostate adenocarcinoma, developed by Dr. Donald Gleason. The scoring system ranges from 6 to 10, with higher scores indicating more aggressive tumors. The score is derived by adding the two most prevalent Gleason grades (patterns 1-5) observed in the tissue sample. Modern reporting typically uses Grade Groups 1-5, which correlate with Gleason scores to provide clearer prognostic information. The Gleason score is crucial for treatment planning and prognosis assessment in prostate cancer management.
Usage
Usage note: Capitalize 'Gleason' as it is an eponym; express as primary+secondary=total (e.g., 3+4=7).
In Context
- "The prostate biopsy revealed adenocarcinoma with a Gleason score of 3+4=7." — Pathology report
- "Risk stratification was based on PSA level, clinical stage, and Gleason score." — Oncology consultation