HIFU
Pronunciation: HY-foo
Also written as: HIFU — high-intensity focused ultrasound
High-intensity focused ultrasound therapy used as a minimally invasive treatment for localized prostate cancer.
Full Definition
High-intensity focused ultrasound (HIFU) is a minimally invasive therapeutic modality that uses focused ultrasound energy to achieve precise thermal ablation of targeted tissue, primarily used for treating localized prostate cancer. The procedure involves transrectal delivery of focused ultrasound beams that generate temperatures of 80-100°C in the focal zone, causing immediate coagulative necrosis while sparing surrounding tissues. HIFU can be used as primary therapy for organ-confined prostate cancer or as salvage therapy following radiation failure. Real-time magnetic resonance imaging guidance enhances precision and monitoring of treatment effects. Potential side effects include urethral stricture, erectile dysfunction, and rarely, rectal injury.
Usage
Usage note: Always spell out on first use in documents; specify guidance method (MR or ultrasound) when relevant.
In Context
- "MR-guided HIFU treatment achieved complete ablation of the target lesion with preservation of neurovascular bundles." — Treatment summary
- "The patient elected HIFU therapy over radical prostatectomy due to desire for minimally invasive treatment." — Treatment planning note