first-pass effect
Also written as: FPE — first-pass effect
Successful achievement of complete recanalization with single device pass during thrombectomy procedures.
Full Definition
The first-pass effect (FPE) refers to achieving complete vessel recanalization (typically TICI 2c-3) with a single pass of the thrombectomy device, without need for additional maneuvers or device deployments. This outcome measure has gained prominence as a key quality indicator in mechanical thrombectomy procedures, as it correlates with improved clinical outcomes, reduced procedure times, and decreased risk of procedural complications. Achieving FPE minimizes vessel manipulation, reduces the risk of clot fragmentation or distal embolization, and preserves endothelial function. Modern thrombectomy techniques and device improvements have significantly increased FPE rates, making it a standard benchmark for procedural success.
Usage
Usage note: Use specific TICI grade criteria when documenting FPE achievement; distinguish from overall procedural success.
In Context
- "The new stent retriever demonstrated a first-pass effect rate of 67% in the randomized trial." — Clinical research publication
- "Aspiration thrombectomy achieved first-pass effect with TICI 3 recanalization in under 15 minutes." — Procedure outcome report