fractional flow reserve
Also written as: FFR — Fractional Flow Reserve
A physiological measurement that assesses the hemodynamic significance of coronary artery stenosis during catheterization.
Full Definition
Fractional flow reserve (FFR) is a pressure-derived index that represents the ratio of maximum blood flow distal to a coronary stenosis compared to normal maximum flow in the same vessel. The measurement is obtained using a pressure-sensitive guidewire positioned distal to the lesion during maximal hyperemia, typically induced with adenosine. An FFR value ≤0.80 indicates hemodynamically significant stenosis that would benefit from revascularization. FFR-guided percutaneous coronary intervention has been shown to improve clinical outcomes and reduce unnecessary stent procedures compared to angiography-guided treatment alone.
Usage
Usage note: FFR values should always be reported to two decimal places in procedural documentation.
In Context
- "FFR measurement revealed a value of 0.76, confirming the hemodynamic significance of the mid-LAD stenosis." — Catheterization report
- "The FAME trial established fractional flow reserve as the gold standard for physiological lesion assessment." — Clinical review article