antiarrhythmic
Pronunciation: /ˌæntiəˈrɪðmɪk/
A class of medications used to suppress or prevent abnormal heart rhythms by modifying cardiac electrical activity.
Full Definition
Antiarrhythmic drugs are a diverse group of medications classified into four main classes (I-IV) based on their mechanism of action on cardiac ion channels. Class I agents block sodium channels, Class II are beta-blockers, Class III block potassium channels, and Class IV are calcium channel blockers. These medications work by altering the electrical properties of cardiac tissue to suppress arrhythmias or prevent their recurrence. Selection of appropriate antiarrhythmic therapy depends on the type of arrhythmia, underlying cardiac condition, and patient-specific factors. Many antiarrhythmic drugs have proarrhythmic potential and require careful monitoring.
Usage
Usage note: Can be used as both noun and adjective; hyphenated when used as compound adjective.
In Context
- "The patient was started on a Class III antiarrhythmic for recurrent atrial fibrillation." — Medication management note
- "Antiarrhythmic therapy was discontinued due to proarrhythmic effects." — Drug reaction report