amiodarone
Pronunciation: am-ee-OH-da-rone
A class III antiarrhythmic medication with multi-channel blocking properties used for various atrial and ventricular arrhythmias.
Full Definition
Amiodarone is a potent antiarrhythmic medication classified as a class III agent due to its primary action of blocking potassium channels and prolonging cardiac action potential duration and refractoriness. However, it also exhibits properties of all four Vaughan Williams classes, blocking sodium channels, beta-adrenergic receptors, and calcium channels. Amiodarone is effective for both atrial and ventricular arrhythmias and is often considered when other antiarrhythmic agents have failed or are contraindicated. The drug has a very long half-life and complex pharmacokinetics, requiring careful monitoring for potentially serious side effects including thyroid dysfunction, pulmonary toxicity, hepatotoxicity, and ocular complications.
Usage
Usage note: Monitor for toxicity; specify loading versus maintenance dosing; document baseline organ function.
In Context
- "Amiodarone was initiated for recurrent ventricular tachycardia refractory to other agents." — Medication administration record
- "Baseline thyroid and pulmonary function tests are required before starting amiodarone therapy." — Pre-treatment protocol