Intermediate Technical In the Industry Vocabulary Test

lymphovascular space invasion

Also written as: LVSI — lymphovascular space invasion

The presence of cancer cells within lymphatic or blood vessel spaces, indicating increased risk of metastasis.

Full Definition

Lymphovascular space invasion (LVSI) refers to the histopathological finding of tumor cells present within the lumens of lymphatic vessels or small blood vessels. This feature is associated with increased risk of lymph node metastasis and distant recurrence in breast cancer. LVSI is identified during microscopic examination of tumor specimens and is reported as present or absent in pathology reports. The presence of LVSI may influence treatment decisions, particularly regarding the need for chemotherapy in early-stage breast cancer, and is incorporated into some prognostic scoring systems.

Usage

Usage note: Distinguished from 'lymphovascular invasion' which may refer to vessel wall invasion rather than space invasion.

In Context

"Pathology revealed lymphovascular space invasion, supporting the decision for adjuvant chemotherapy." — Multidisciplinary team discussion
"The presence of lymphovascular space invasion was identified as an independent prognostic factor." — Research publication

Also known as

LVSI vascular invasion angiolymphatic invasion

Contrasted with

absence of vascular invasion

Don't confuse with

lymphatic invasion perineural invasion dermal lymphatic invasion

lymphovascular invasion ← Back to glossary mammographic density