tamoxifen
Pronunciation: tuh-MOK-si-fen
A selective estrogen receptor modulator used as hormone therapy for estrogen receptor-positive breast cancer.
Full Definition
Tamoxifen is a selective estrogen receptor modulator (SERM) that acts as an estrogen antagonist in breast tissue while having estrogenic effects in other tissues such as bone and uterus. It is used for both treatment and prevention of hormone receptor-positive breast cancer in premenopausal and postmenopausal women. Tamoxifen is typically given orally for 5-10 years as adjuvant therapy. Common side effects include hot flashes, increased risk of blood clots, and slightly increased risk of endometrial cancer. It remains a cornerstone of breast cancer treatment despite the availability of newer agents.
Usage
Usage note: Monitor for thromboembolic events and endometrial changes during treatment.
In Context
- "The patient will continue tamoxifen therapy for five years with annual gynecologic monitoring." — Treatment plan
- "Tamoxifen was discontinued due to development of deep vein thrombosis." — Adverse event report