oncogene addiction
The phenomenon where tumor cells become dependent on continued oncogene activity for survival and proliferation, despite additional genetic alterations.
Full Definition
Oncogene addiction describes the paradoxical dependence of cancer cells on the continued expression or activity of the very oncogenes that initially drove their transformation, even as tumors acquire additional mutations and become genetically complex. This addiction creates therapeutic vulnerability, as inhibiting the addicting oncogene can trigger apoptosis or growth arrest despite the presence of other oncogenic alterations. Classic examples include BCR-ABL addiction in chronic myeloid leukemia and EGFR addiction in lung adenocarcinoma. The molecular basis involves rewiring of cellular signaling networks around the dominant oncogene, creating dependencies that can be exploited therapeutically. Understanding addiction patterns is crucial for selecting targeted therapies and predicting treatment responses.
Usage
Usage note: Emphasize therapeutic vulnerability despite genetic complexity.
In Context
- "The tumor displayed clear oncogene addiction to MYC, making it vulnerable to targeted inhibition." — Therapeutic vulnerability assessment
- "Despite multiple mutations, oncogene addiction to the fusion protein persisted throughout disease progression." — Targeted therapy rationale