adipokine
Pronunciation: AD-ih-poh-kyne
Bioactive proteins secreted by adipose tissue that regulate metabolism, inflammation, and insulin sensitivity.
Full Definition
Adipokines are signaling proteins produced and secreted by adipose tissue that play crucial roles in energy homeostasis, glucose and lipid metabolism, and inflammatory processes. These molecules include both pro-inflammatory cytokines like tumor necrosis factor-alpha and interleukin-6, as well as anti-inflammatory factors such as adiponectin. The dysregulated secretion of adipokines in obesity contributes to insulin resistance, type 2 diabetes, and cardiovascular disease. Understanding adipokine biology has become fundamental to cardiometabolic medicine as these factors represent potential therapeutic targets and biomarkers for metabolic dysfunction.
Usage
Usage note: Singular form; plural is 'adipokines'. Not synonymous with general cytokines or hormones.
In Context
- "Altered adipokine profiles in obese patients contribute to systemic insulin resistance." — Research manuscript
- "The study measured various adipokines to assess the metabolic effects of weight loss surgery." — Bariatric surgery research