very low-density lipoprotein
Also written as: VLDL — very low-density lipoprotein
Lipid-carrying particle that transports triglycerides and is elevated in diabetic dyslipidemia.
Full Definition
Very low-density lipoprotein (VLDL) is a class of lipoprotein particles produced by the liver that primarily carries triglycerides from the liver to peripheral tissues. In cardiometabolic disorders, particularly insulin resistance and type 2 diabetes, VLDL production is increased due to enhanced hepatic fatty acid synthesis and impaired triglyceride clearance. Elevated VLDL levels contribute to the characteristic diabetic dyslipidemia pattern of high triglycerides, low HDL cholesterol, and small dense LDL particles, significantly increasing cardiovascular disease risk through atherogenic mechanisms.
Usage
Usage note: Commonly abbreviated as VLDL in clinical contexts; distinguish from LDL and IDL.
In Context
- "Elevated very low-density lipoprotein levels correlated with hepatic insulin resistance." — lipid metabolism study
- "VLDL particle size and concentration were measured using advanced lipoprotein analysis." — cardiovascular risk assessment